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  • Title: Canadian clinical trial of antilymphocyte globulin in human cadaver renal transplantation.
    Author: Taylor HE, Ackman CF, Horowitz I.
    Journal: Can Med Assoc J; 1976 Dec 18; 115(12):1205-8. PubMed ID: 793705.
    Abstract:
    A multicentre, randomized clinical trial of antilymphocyte globulin (ALG) was conducted among patients who had undergone cadaver kidney transplantation; follow-up was continued for a minimum of 1 year. Of the 179 patients 92 were given conventional treatment only, while 87 were given in addition ALG (from a standardized, highly immunosuppressive, common pool of equine ALG), 20 mg/kg-d intravenously for 10 days after transplantation. The ALG-treated group had better accumulated graft survival, fewer nephrectomies, better graft function, less than half the number of acute rejection episodes and less prednisone use. There was a beneficial drug (ALG)-related effect in both the graft and the host during the first 3 months after transplantation.
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