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  • Title: Effect of opioid peptide antisera on nitrous oxide antinociception in rats.
    Author: Hara S, Gagnon MJ, Quock RM, Shibuya T.
    Journal: Pharmacol Biochem Behav; 1994 Jul; 48(3):699-702. PubMed ID: 7938124.
    Abstract:
    This study was performed to examine the effects of ICV injection of antiserum against beta-endorphin (beta-EP) or methionine-enkephalin (ME) on nitrous oxide-induced antinociception in rats using the hot plate test. The injection of beta-EP antiserum reversed the antinociceptive effect of nitrous oxide in a dose-related manner up to 200 micrograms/rat. However, antagonism of nitrous oxide by 400 micrograms beta-EP antiserum was comparable to that produced by 200 micrograms. On the other hand, similar amounts of ME antiserum had little effect against nitrous oxide antinociception. These findings suggest that beta-EP may play an important role in the antinociceptive effect of nitrous oxide.
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