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  • Title: [First experiences with BS 100-141, a new antihypertensive substance].
    Author: Esch I.
    Journal: Int J Clin Pharmacol Biopharm; 1976 Sep; 14(2):109-12. PubMed ID: 793999.
    Abstract:
    The administration of a new guanidine derivate, BS 100-141, to 20 patients resulted in a statistically highly significant reduction of blood pressure. A comparative clinical trial of BS 100-141 and alpha-methyl-DOPA showed BS 100-141 to be more efficient in lowering the arterial pressure than alpha-methyl-DOPA, especially when the drug was used in the second period of treatment. In the majority of the patients treated with BS 100-141 a slight increase in blood glucose concentration, not exceeding the upper limits of normal values, was found.
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