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  • Title: Carrier-state infection of feline T-lymphoblastoid cells with feline calicivirus.
    Author: Kawaguchi Y, Tohya Y, Horimoto T, Maeda K, Miyazawa T, Mikami T.
    Journal: Vet Microbiol; 1994 Jun; 40(3-4):379-86. PubMed ID: 7941301.
    Abstract:
    The susceptibility of feline T lymphocytes to feline calicivirus (FCV) in vitro was investigated using feline T-lymphoblastoid cell lines, namely MYA-1 and FL74 cells. The virus titers of supernatants in FCV-infected MYA-1 and FL74 cell cultures increased rapidly, and FCV antigens were also detected in the FCV-infected cells. There were slight differences in the molecular weights of capsid proteins expressed in FCV-infected MYA-1, FL74 and Crandell feline kidney cells. MYA-1 and FL74 cells were productively and persistently infected with FCV, and FCV antigens were observed in the FCV-infected cells for more than one month. At 3 months post infection, FCV-infected FL74 cells that stopped producing infectious FCV could be reinfected with FCV. However, no cytopathic effects were observed.
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