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  • Title: [Mediator liberation at the myoneural junctions of the frog sartorius muscle when axoplasmic transport has been disrupted with colchicine].
    Author: Volkov EM, Poletaev GI, Ulumbekov EG.
    Journal: Biull Eksp Biol Med; 1978; 86(7):19-22. PubMed ID: 79423.
    Abstract:
    Colchicine application to the nerve innervating the frog sartorius muscle leads to reduction of the differences in functional condition of the myoneural synapses of this muscle by the signs of quantum content of the end plate potential (EPP) and by the changes of the EPP amplitudes in high frequency stimulation. Along with this there occurs a rarefaction of the frequency of miniature potential of the end plate, and reduction of its amplitude. Apparently, the latter is caused by reduction of effective resistance of the postsynaptic membrane. Changes of the induced and spontaneous secretion of the mediator are connected with disturbances of the axoplasmic transport just in the somatic nerve fibers.
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