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  • Title: [The prevention of peritoneal dissemination of gastric cancer with intraperitoneal activated carbon particles absorbing mitomycin C].
    Author: Ohgaki M, Imanishi T, Ohyama T, Tsujimoto H, Ozaki K, Chohei S, Shimotsuma M, Hagiwara A, Takahashi T.
    Journal: Gan To Kagaku Ryoho; 1994 Sep; 21(13):2320-2. PubMed ID: 7944469.
    Abstract:
    A new drug dosage form comprising activated carbon particles absorbing mitomycin C (MMC-CH) has the advantage of being retained in the peritoneal cavity and distributes a larger amount of mitomycin C for a long time. Some 113 patients with gastric cancer and serosal infiltration were randomly assigned intraperitoneal treatment with MMC-CH and no anti-cancer drugs. There were significant differences in survival rate between the patients who have no visible peritoneal dissemination with MMC-CH and without. Thus, intraoperative intraperitoneal treatment with MMC-CH improves survival after gastrectomy for gastric cancer and seems effective against peritoneal recurrence.
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