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  • Title: Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I.
    Author: Ishihama H, Suzuki Y, Muramatsu K, Nagai M, Kokubo M, Shiraya H, Kawakita A, Nishimura Y, Imamura T, Kobayashi M.
    Journal: Arch Dis Child; 1994 Aug; 71(2):144-6. PubMed ID: 7944536.
    Abstract:
    Insulin-like growth factor I (IGF-I) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF-I receptor. A girl with typical type A insulin resistant syndrome was treated with IGF-I for two years and the treatment was effective in ameliorating hyperglycaemia. Overproduction of testosterone in polycystic ovaries was aggravated with this treatment, however. Therefore, IGF-I treatment may be used for glycaemic control but with caution because of its possible side effect of aggravating hyperandrogenism in these patients.
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