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  • Title: Effects of hypoxia on platelet activation in pilots.
    Author: Shen D, Wang Y.
    Journal: Aviat Space Environ Med; 1994 Jul; 65(7):646-8. PubMed ID: 7945133.
    Abstract:
    In order to evaluate the effect of hypoxia on platelet activation, 53 pilots were chosen for this study. Thirty were selected as the hypoxic group, and the other 23 as a control group. The plasma concentration of thromboxane B2(TXB2), 6-keto-prostaglandin f1 alpha (6-keto-PGF1 alpha), beta-thrombo-globulin (BTG) and platelet factor 4 (PF4) were measured during altitude chamber tests. After staying at 5000 m for 15 min, the plasma level of TXB2, BTG and PF4 increased significantly over pre-test levels (p < 0.01), but 6-keto-PGF1 alpha had no distinct change (p > 0.05). These changes indicate that moderate acute hypoxia causes increases in platelet activation, but has less effects on the endothelial cells.
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