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  • Title: Stereospecific reduction of R(+)-thioctic acid by porcine heart lipoamide dehydrogenase/diaphorase.
    Author: Schempp H, Ulrich H, Elstner EF.
    Journal: Z Naturforsch C J Biosci; 1994; 49(9-10):691-2. PubMed ID: 7945680.
    Abstract:
    R(+)-thioctic acid is the naturally occurring cofactor in alpha-ketoacid dehydrogenases. We show both photometrically by NADH+H+ oxidation and by HPLC product analysis that this enantiomer is rapidly reduced by NADH+H+ catalyzed by porcine heart lipoamide dehydrogenase/diaphorase. The racemate exhibits approximately 40% activity as compared to the R(+) form while the S(-) enantiomer photometrically shows little activity and yields no detectable reduced lipoic acid.
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