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  • Title: Cytotoxic activity of two new lipophilic steroid nitrogen carbamates incorporated into low-density lipoprotein.
    Author: Lundberg B.
    Journal: Anticancer Drug Des; 1994 Oct; 9(5):471-6. PubMed ID: 7945729.
    Abstract:
    Low-density lipoprotein (LDL) is a potential drug carrier in cancer chemotherapy. Two novel cytotoxic lipophilic steroid derivatives with two nitrogen carbamate groups on a C-17 side chain were successfully incorporated into LDL using a reassembly technique. The antineoplastic activity of the new agents against T-47D breast cancer cells in culture was approximately twice that of a previously characterized compound with only one such group.
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