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  • Title: First trimester diagnosis of fetal nuchal edema. Report of 29 cases.
    Author: Brun JL, Saura R, Horovitz J, Maugey B, Taine L, Roux D, Vergnaud A.
    Journal: Fetal Diagn Ther; 1994; 9(4):246-51. PubMed ID: 7945905.
    Abstract:
    During a 4-year period, 29 fetal nuchal edemas were observed, associated with other ultrasound abnormalities in 7 cases (24%). Fetal karyotypes were abnormal in 10 cases: 6 trisomy 21; 3 trisomy 18, and 1 Turner's syndrome. Isolated fetal nuchal edema was associated with aneuploidy in 4 cases: 3 trisomy 21, and 1 trisomy 18. The average age of the women carrying a fetus with nuchal edema associated or not with a trisomy 21 was 38.3 and 30.8 years, respectively. These results are similar to those found in the literature. It would appear that maternal age is a better marker in trisomy 21 screening than isolated fetal nuchal edema.
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