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  • Title: Sustained-release isradipine compared with spirapril in the treatment of elderly patients with isolated systolic hypertension.
    Author: Tomlinson B, Woo J, Critchley JA, Or KK, Chan TY, Sanderson JE.
    Journal: Am J Hypertens; 1994 Jul; 7(7 Pt 2):35S-39S. PubMed ID: 7946177.
    Abstract:
    The benefits of treating isolated systolic hypertension (ISH) have been established, but the most appropriate choice of drug is still uncertain. For this reason, a sustained-release formulation of isradipine was compared with spirapril in a double-blind randomized study in elderly Chinese patients with ISH. The dosage was titrated if necessary after 4 weeks of treatment. The reduction in systolic/diastolic blood pressure after 8 weeks was similar for both treatments--20/10 mm Hg with isradipine versus 24/6 mm Hg with spirapril--measured in the supine position. There were no orthostatic symptoms and both treatments were well tolerated.
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