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  • Title: Opioid antagonist effects on self-injury in adults with mental retardation: response form and location as determinants of medication effects.
    Author: Thompson T, Hackenberg T, Cerutti D, Baker D, Axtell S.
    Journal: Am J Ment Retard; 1994 Jul; 99(1):85-102. PubMed ID: 7946257.
    Abstract:
    The opioid antagonist naltrexone was administered to 8 adults with severe or profound mental retardation and extensive histories of self-injurious behavior. Five-minute behavioral samples were observed randomly out of every hour from 8 a.m. through 3 p.m., Monday through Friday, for four 2-week phases (baseline, placebo, 50 mg, and 100 mg). During naltrexone administration, there were fewer days with frequent head-banging and self-biting, whereas there were more days on which blows to the head or self-biting were infrequent. Self-injurious participants slept 1.38 hours less per night during baseline, which was unaffected by naltrexone.
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