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  • Title: Emepronium bromide (Cetiprin) as a postoperative spasmolytic agent in transvesical prostatectomy.
    Author: Syversen JH, Mollestad E, Semb LS.
    Journal: Scand J Urol Nephrol; 1976; 10(3):201-3. PubMed ID: 795015.
    Abstract:
    To find out whether Cetiprin reduces the vesical spasms seen after cystotomias, a double-blind investigation including 22 men was carried out. Eleven of the men were given 25 mg Cetiprin i.m. twice a day for 2 days after transvesical prostatectomy, then 200 mg orally 3 times a day the following 12 days. The rest of the men, 11 patients, received placebo. In the Cetiprin group 9 patients had no vesical spasm postoperatively, whereas 1 had moderate and 1 had severe spasms. Only 4 patients were without spasms in the control group, whereas 5 had moderate and 2 severe spasms. The postoperative reduction of the bladder volume were counteracted by Cetiprin. No significant influence on liver- or kidney function was seen with the dosages mentioned.
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