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  • Title: Controlled trial of D-penicillamine in rheumatoid arthritis. Dose effect and the role of zinc.
    Author: Mery C, Delrieu F, Ghozlan R, Saporta L, Simon F, Amor B, Menkes CJ, Delbarre F.
    Journal: Scand J Rheumatol; 1976; 5(4):241-7. PubMed ID: 795022.
    Abstract:
    The findings are reported of a controlled clinical trial comparing in 66 rheumatoid arthritis patients 0 g (placebo), and 0.50 g a day and 1 g a day of penicillamine. Each of these groups has been subdivided into two, one part receiving 5 mg a day of zinc metal supplement, the other a placebo. The trial was planned to be double-blind, and for each patient to take part for 4 months. The results prove the effectiveness of penicillamine in rheumatoid arthritis. 0.50 g a day has the same effect as 1 g a day but gives less side effects. Zinc supplement inhibits the clinical effects of penicillamine but does not prevent the side effects.
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