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  • Title: Signal transduction and cell fate specification during Caenorhabditis elegans vulval development.
    Author: Eisenmann DM, Kim SK.
    Journal: Curr Opin Genet Dev; 1994 Aug; 4(4):508-16. PubMed ID: 7950317.
    Abstract:
    A receptor tyrosine kinase/Ras signaling pathway controls the specification of vulval cell fates in Caenorhabditis elegans. Recently, C. elegans genes encoding proteins with similarity to mammalian Raf (lin-45), mitogen-activated protein kinase (mpk-1/sur-1), and an HNF-3 transcription factor (lin-31) have been identified and shown to act downstream of let-60 (ras) in this pathway. These genetically identified gene products bridge the gap between signal transduction at the plasma membrane and the control of cell fate specification in the nucleus.
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