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  • Title: Correlations between akathisia and residual psychopathology: a by-product of neuroleptic-induced dysphoria.
    Author: Newcomer JW, Miller LS, Faustman WO, Wetzel MW, Vogler GP, Csernansky JG.
    Journal: Br J Psychiatry; 1994 Jun; 164(6):834-8. PubMed ID: 7952993.
    Abstract:
    Patients developing neuroleptic-induced akathisia have been reported to show higher levels of psychopathology. We sought to replicate this finding and determine its symptom specificity. We confirmed a significant relationship between ratings of akathisia and total score on the Brief Psychiatric Rating Scale (BPRS) during both acute and maintenance neuroleptic treatment. Using stepwise regression models, BPRS anxious-depressive subscale scores were the strongest predictors of akathisia during both treatment conditions. Paranoid subscale scores predicted akathisia only during maintenance treatment. These results suggest that neuroleptic-induced dysphoria largely explains the relationship between akathisia and residual psychopathology during both acute and maintenance neuroleptic treatment.
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