These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Type X collagen in fracture callus and the effects of experimental diabetes.
    Author: Topping RE, Bolander ME, Balian G.
    Journal: Clin Orthop Relat Res; 1994 Nov; (308):220-8. PubMed ID: 7955687.
    Abstract:
    Studies of fracture repair in diabetes have shown decreased mechanical strength and total collagen in the callus. Type I and Type II collagen are synthesized by bone and cartilage cells, respectively, while Type X collagen is synthesized by hypertrophic chondrocytes in endochondral ossification. A standardized fracture model was chosen to investigate extracellular matrix changes during fracture healing of normal and diabetic rats. Histological examination of the fracture callus in both normal and diabetic animals showed progression from a fibrous tissue to cartilage to bone. An antiserum to Type X collagen was prepared, and immunostaining was observed in the matrix surrounding the hypertrophic chondrocytes. Fracture calluses from streptozotocin induced diabetic rats had similar histology and immunostaining to controls. Radiolabelled proteins were extracted from the calluses of normal and diabetic rats to measure Type X collagen. Type X collagen expression in the fracture callus of normal rats reached a maximum at day fourteen and was decreased by between 54% and 70% in the fracture callus of diabetic rats. The decrease in Type X collagen synthesis may have a role in the defect of fracture healing in diabetes.
    [Abstract] [Full Text] [Related] [New Search]