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  • Title: Endothelin ETA and ETB receptors in subarachnoid hemorrhage-induced cerebral vasospasm.
    Author: Zuccarello M, Lewis AI, Rapoport RM.
    Journal: Eur J Pharmacol; 1994 Jun 23; 259(1):R1-2. PubMed ID: 7957585.
    Abstract:
    The relative roles of endothelin ETA and ETB receptor activation in cerebral vasospasm following subarachnoid hemorrhage were investigated in the rabbit. The endothelin ETA receptor antagonist, BQ610 (1 microM; homopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-OH), and the endothelin ETA/ETB receptor antagonist, PD145065 (1 microM; Ac-D-Bhg-L-Leu-L-Asp-L-Ile-L-Ile-L-Trp), relaxed the vasospastic basilar artery in situ by 45% and 87%, respectively. These results suggest that subarachnoid hemorrhage-induced vasospasm of the rabbit basilar artery is due to activation of both endothelin ETA and ETB receptors.
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