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  • Title: Inhibitory effect of vapiprost on contractile responses of isolated dog renal arteries to thromboxane A2 analogue, U46619.
    Author: Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Itomine T, Uza M, Toyama F, Higuchi M.
    Journal: Gen Pharmacol; 1994 Jul; 25(4):617-22. PubMed ID: 7958719.
    Abstract:
    1. Cumulative administrations of U46619, a thromboxane A2 analogue, and prostaglandin (PG) F2 alpha produced concentration-dependent contractions of isolated dog renal arterial preparations, which were significantly and concentration-dependently inhibited by vapiprost. 2. A bolus administration of U46619 or PGF2 alpha produced sustained contracture of these preparations, which was concentration-dependently relaxed by cumulative vapiprost. 3. Results indicate that vapiprost inhibits U46619- and PGF2 alpha-induced dog renal arterial contractions through antagonism for so-called TP receptors.
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