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  • Title: Growth factors and pericellular components as a local signalling relay in the action of systemic hormones.
    Author: Chambaz EM, Cochet C, Souchelnitskiy S, Defaye G, Feige JJ.
    Journal: Horm Res; 1994; 42(1-2):35-8. PubMed ID: 7959632.
    Abstract:
    Recent years have shown that peptidic signals, originally identified as growth factors, may represent a local signalling system involved in the regulation of cell function under the dependence of systemic hormones. As an example, (i) adrenocortical cells are highly sensitive to transforming growth factor-beta (TGF beta) which is a powerful inhibitor of their differentiated functions; (ii) adrenocortical cells produce and secrete TGF beta, which is present in the adrenal cortex in situ; (iii) adrenocorticotropin (ACTH), which is the best known positive effector of adrenocortical functions induces an up-regulation of TGF beta receptors in adrenocortical cells. Altogether, these observations suggest that TGF beta may be a local signalling system acting in balance with the systemic hormone ACTH to eventually tune the ability of adrenocortical cells to produce corticosteroids.
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