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  • Title: Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain.
    Author: Richards AJ, al-Imara L, Carter NP, Lloyd JC, Leversha MA, Pope FM.
    Journal: Genomics; 1994 Jul 01; 22(1):237-9. PubMed ID: 7959779.
    Abstract:
    Laminin is a basement membrane glycoprotein composed of three nonidentical chains, A, B1, and B2. Variant chains such as merosin and S-laminin have been found in different tissues. We have isolated a cDNA encoding a novel laminin A variant that hybridizes to a 6.45-kb mRNA. Using amplification of genomic DNA and flow-sorted chromosomes we have assigned the gene (LAMA4) for this new laminin A variant to chromosome 6. Fluorescence in situ hybridization of a YAC clone further localized the gene to 6q21.
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