These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Clozapine, negative symptoms, and extrapyramidal side effects.
    Author: Kane JM, Safferman AZ, Pollack S, Johns C, Szymanski S, Kronig M, Lieberman JA.
    Journal: J Clin Psychiatry; 1994 Sep; 55 Suppl B():74-7. PubMed ID: 7961579.
    Abstract:
    The importance of persistent negative symptoms in schizophrenia as a limiting factor in psychosocial and vocational rehabilitation has been increasingly emphasized. As a result, treatment trials and new drug development programs are focusing more attention on negative symptoms. Unfortunately, there is enormous phenomenological overlap between negative symptoms and neuroleptic-induced parkinsonism. We report data from a cohort of 56 clozapine-treated patients demonstrating significant correlations between measures of akinesia and anergia. Despite an average drug washout of over 2 weeks, the persistence of drug-induced parkinsonism can confound the assessment of therapeutic drug effects on negative symptoms.
    [Abstract] [Full Text] [Related] [New Search]