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  • Title: A multicenter double-blind trial of paroxetine versus amitriptyline in depressed inpatients.
    Author: Stuppaeck CH, Geretsegger C, Whitworth AB, Schubert H, Platz T, König P, Hinterhuber H, Fleischhacker WW.
    Journal: J Clin Psychopharmacol; 1994 Aug; 14(4):241-6. PubMed ID: 7962679.
    Abstract:
    The phenylpiperidine derivative paroxetine is a selective serotonin reuptake inhibitor. In a double-blind 6-week trial, paroxetine was compared with amitriptyline in hospitalized patients suffering from major depression (DSM-III). One hundred fifty-three patients were enrolled in the study in seven centers in Austria and Germany. Results showed similar efficacy of both drugs after 6 weeks. The differences between groups in Montgomery-Asberg Depression Rating Scale and Clinical Global Impression ratings did not reach statistical significance at any time. Side effects were distributed similarly but with a significantly higher incidence of anticholinergic effects in patients treated with amitriptyline (p < or = 0.001), whereas agitation and insomnia were registered more often in the paroxetine group. This study supports the antidepressive efficacy of paroxetine in a sample of severely depressed inpatients.
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