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  • Title: Synthesis of imidazo[2,1-b]thiazoles and thiazolines as potential antiulcer agents.
    Author: Andreani A, Rambaldi M, Leoni A, Locatelli A, Pifferi G.
    Journal: J Pharm Belg; 1994; 49(4):308-14. PubMed ID: 7965580.
    Abstract:
    The replacement of the imidazole ring of cimetidine with a bicyclic system (imidazo[1,2-a]pyridine), reported in the literature, produced compounds endowed with potent antiulcer activity. In this paper we describe the synthesis of imidazo [2,1-b]thiazoles and thiazolines bearing the side chain of metiamide, cimetidine and ranitidine: the compounds obtained, tested on gastric lesions induced in rats by ethanol and by stress, were devoid of antiulcer activity.
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