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  • Title: Cocaethylene in meconium specimens.
    Author: Lewis DE, Moore CM, Leikin JB.
    Journal: J Toxicol Clin Toxicol; 1994; 32(6):697-703. PubMed ID: 7966527.
    Abstract:
    Cocaethylene, a metabolite of cocaine and ethanol, exhibits cardiac and neurobehavioral effects. In order to determine the prevalence of this compound in meconium specimens, samples which gave a positive result for benzoylecgonine using fluorescence polarization immunoassay were analyzed by gas chromatography/mass spectrometry for cocaine, cocaethylene and benzoylecgonine. Deuterated cocaine, cocaethylene and benzoylecgonine were used as internal standards. Gas chromatography/mass spectrometry cutoff concentrations of 5.0 ng/g were utilized for all analytes. Of the 361 specimens which consecutively confirmed positive for cocaine or benzoylecgonine, 114 (31.6%) tested positive for cocaethylene. Further, cocaethylene accumulates in greater concentrations in meconium than urine, and is a useful analyte for identifying fetal alcohol exposure.
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