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  • Title: Multiple viral core proteins are determinants of reovirus-induced acute myocarditis.
    Author: Sherry B, Blum MA.
    Journal: J Virol; 1994 Dec; 68(12):8461-5. PubMed ID: 7966643.
    Abstract:
    Previously, we showed that the M1 gene (encoding a viral core protein, mu 2, whose function is unknown) was associated with the efficiently myocarditic phenotype of a reovirus variant, 8B. Here, we have extended our genetic analysis of 8B and conducted genetic analyses of two other reovirus strains (T1L [serotype 1 strain Lang] and Abney). Our results demonstrate that multiple viral core proteins are determinants of reovirus-induced myocarditis. In contrast to our previous association of mu 2 with induction of myocarditis, this provides strong evidence that a core function achieved through the interaction of multiple core proteins is responsible for induction of the disease.
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