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  • Title: The calcemic response to PTH in the rat: effect of elevated PTH levels and uremia.
    Author: Bover J, Jara A, Trinidad P, Rodriguez M, Martin-Malo A, Felsenfeld AJ.
    Journal: Kidney Int; 1994 Aug; 46(2):310-7. PubMed ID: 7967341.
    Abstract:
    Secondary hyperparathyroidism (2 degrees HPT) is a consistent finding in renal failure. A decreased calcemic response (CR) to parathyroid hormone (PTH) contributes to the development of 2 degrees HPT. Since parathyroidectomy (PTX) corrects the decreased CR to PTH in azotemic animals, down-regulation of PTH receptors induced by an elevation of PTH has been advanced as an important factor in the development of 2 degrees HPT. The goal of the study was to determine in azotemic rats whether a progressive reduction of PTH improves the CR to PTH and whether the maintenance of normal PTH levels corrects the CR to PTH. Seven groups of pair-fed rats were studied. Three groups of rats had normal renal function (NRF groups) and received either a high phosphorus (HPD-NRF), a moderate phosphorus (MPD-NRF), or a low phosphorus (LPD-NRF) diet. Three azotemic (NX) groups received similar diets (HPD-NX, MPD-NX and LPD-NX groups) in order to vary the magnitude of 2 degrees HPT. A PTX was performed in a fourth azotemic group (PTX-NX) to induce the complete absence of PTH. After 14 to 16 days on the maintenance diets, the CR to PTH was determined with a 48 hour infusion of 1-34 rat PTH.(ABSTRACT TRUNCATED AT 250 WORDS)
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