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  • Title: Discrepancy between PNMT presence and relative lack of adrenaline production in extra-adrenal pheochromocytoma.
    Author: Funahashi H, Imai T, Tanaka Y, Tobinaga J, Wada M, Matsuyama T, Tsukamura K, Yamada F, Takagi H, Narita T.
    Journal: J Surg Oncol; 1994 Nov; 57(3):196-200. PubMed ID: 7967610.
    Abstract:
    Among catecholamine synthesizing enzymes, phenylethanolamine-N-methyltransferase (PNMT) exists only in adrenal and extra-adrenal pheochromocytoma has been believed not to produce adrenaline. However, adrenaline production is clinically active in some extra-adrenal cases. To investigate this controversy, the localization of catecholamine synthesizing enzymes was studied by immunohistochemical staining in extra-adrenal and adrenal cases. The results showed that PNMT was expressed not only in many cases of adrenal pheochromocytoma, but also in extra-adrenal pheochromocytoma. It is suspected that little adrenaline production in extra-adrenal cases is attributable to a lack of a good environment for the activation of PNMT by a high concentration of glucocorticoids.
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