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  • Title: Vitamin D modulates the effects of follicle-stimulating hormone on Sertoli cell function and testicular growth in Siberian hamsters.
    Author: Majumdar SS, Bartke A, Stumpf WE.
    Journal: Life Sci; 1994; 55(19):1479-86. PubMed ID: 7968215.
    Abstract:
    Sertoli cells from immature (18-20 day old) Siberian hamsters (Phodopus sungorus) raised in a long photoperiod (LD; 16hL:8hD) or a short photoperiod (SD; 6hL:18hD) were cultured and exposed to follicle-stimulating hormone (FSH) and/or vitamin D3 (D3) in vitro. D3 did not stimulate lactate production when added alone, but significantly augmented the stimulatory action of FSH on lactate production by Sertoli cells from both LD- and SD-exposed hamsters. Hamsters raised in LD or SD were injected daily with D3 for 10 days starting at 18 days of age. This treatment resulted in a significant increase in the testicular weight of hamsters raised in LD in which circulating FSH levels are high. In contrast, testicular weight was not altered by D3 treatment in SD hamsters in which circulating levels of FSH are low. We conclude that D3, probably after hydroxylation to 1,25(OH)2 vitamin D3, modulates the action of FSH on testicular growth and Sertoli cell function.
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