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  • Title: Caffeine and propranolol block the increase in rat pineal melatonin production produced by stimulation of adenosine receptors.
    Author: Babey AM, Palmour RM, Young SN.
    Journal: Neurosci Lett; 1994 Jul 18; 176(1):93-6. PubMed ID: 7970245.
    Abstract:
    The adenosine agonist 5'-N-ethylcarboxamidoadenosine (NECA) injected i.p. during the light period increased rat pineal melatonin levels and this increase was blocked by simultaneous administration of the non-selective adenosine receptor antagonist caffeine. A single dose of the adenosine A1 agonist cyclopentyladenosine had no effect on nocturnal melatonin production. The NECA-stimulated increase was also blocked by the beta-adrenergic receptor antagonist propranolol. Given alone, neither caffeine nor propranolol had any effect on melatonin levels. The results point to an intermediate role for beta-adrenergic receptors in the adenosine-stimulated increase of melatonin production.
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