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  • Title: Value of immune-complex assays in diagnosis and management.
    Author: Pussell BA, Lockwood CM, Scott DM, Pinching AJ, Peters DK.
    Journal: Lancet; 1978 Aug 12; 2(8085):359-64. PubMed ID: 79721.
    Abstract:
    Two complement-dependent assays for circulating immune complexes, the C1q-binding assay and the conglutinin binding, were used to study patients with suspected immune-complex disease. Complexes were detected most frequently in multisystem disease such as infective endocarditis (69%) and systemic lupus erythematosus (60%), and less frequently in isolated nephritis (26% of membrano-proliferative nephritis). Sequential estimations in 32 patients showed that concentrations of circulating immune complexes correlated with disease activity and were useful in monitoring therapy.
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