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  • Title: Synthesis and cytotoxic activity of new isothiazolo[5,4-d]pyrimidine derivatives.
    Author: Lipnicka U, Regiec A, Machon Z.
    Journal: Pharmazie; 1994 Sep; 49(9):642-6. PubMed ID: 7972309.
    Abstract:
    The synthesis of new 5-amino-3-methylisothiazolo[5,4-d]pyrimidines series is reported. The cytotoxic activity of these compounds has been determined on the two tumor cell lines (P-388 and KB). Two representative compounds 7 and 8 displayed a significant cytotoxic action. The results point a possible involvement of structural features in the inhibition effect against tumors.
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