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  • Title: [The differential assessment of the state of lipid peroxidation and of the antioxidant system in patients in the late period after gastric resection].
    Author: Abrahamovych OO, Pavlovs'kyĭ MP, Vyhovs'kyĭ VP, Tymochko MF, Abrahamovych IeS, Stefaniuk VD, Saĭko OIu, Vitkovs'kyĭ VF, Abrahamovych MO, Dziubachyk MI.
    Journal: Lik Sprava; 1994; (3-4):72-5. PubMed ID: 7975544.
    Abstract:
    Studied after stomach resection for ulcer disease in 161 patients were lipid peroxidation (LPO), antioxidant system (AOS) and related parameters characterizing metabolism of carbon (Lactat), protein (piruvat) and fat (fat acids, lipoproteins), an indicator of the dystrophic change degree (acid phosphatase). Revealed in these patients was syndrome of peroxidation, which leads to disturbances of protein, carbon and fat metabolism, destruction of cell membranes. Increased, "normal", weakened LPO was identified in 67.7%, 9.94%, 22.36% of the patients respectively. In patients with an increased LPO statistically significant activation of AOS was established, lactate having increased more than twice, pyruvate remaining unchanged; the level of fat acids and lipoproteins almost doubled. In such a situation it is reasonable to use preparations which activate aerobic glycolysis, and antioxidants of a direct, mild degree, action. In group II patients with more prominent increase in the acid phosphatase activity preference should be given to membrane-stabilizing preparations. In patients with a decreased level of LPO considerable increase in lactate and acid phosphatase was noted. It is recommended that preparations promoting normalization of carbon and lipid metabolism, enhancement of redox processes in the respiratory chain should be included into complex therapy as should be stabilizers of membranes of cell organelles, with biogenic stimulators to follow.
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