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  • Title: [Study on mitoxantrone polycyanoacrylate nanospheres].
    Author: Zhang ZR, Liao GT, Hou SX.
    Journal: Yao Xue Xue Bao; 1994; 29(7):544-9. PubMed ID: 7976360.
    Abstract:
    The mitoxantrone polybutylcyanoacrylate nanosparticles (DHAQ-PBCA-NP) were prepared by emulsion polymerization method. The surface charge, drug loading, morphology, size and size distribution, release characteristics in vitro, stability and distribution in animals of DHAQ-PBCA-NP were studied. The results showed that the mean size was d(av) = 55.23 nm, drug loading was 46.77%, embedding ratio was 84.89%. The surface carried negative charge and the release characteristics in vitro was in accord with two phases kinetics law. The colloidal solution of DHAQ-PBCA-NP can undergo boiling for 30 min sterilization. The radioactivity concentrated mainly in liver after iv 3H-DHAQ-PBCA-NP. The radioactivity in liver tumor was higher than that in the liver tissue. DHAQ-PBCA-NP was observed in parenchymal cell 15 min after iv DHAQ-PBCA-NS. This preparation seems to have important value for increasing the anti-liver tumor effect and decreasing the toxicity of DHAQ.
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