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  • Title: Experimental in situ conditioning of the latissimus dorsi muscle for circulatory assist by multichannel stimulation.
    Author: Koller R, Girsch W, Huber L, Rab M, Stöhr HG, Schima H, Losert UM, Thoma H, Wolner E.
    Journal: Artif Organs; 1994 Jul; 18(7):523-8. PubMed ID: 7980097.
    Abstract:
    This study was undertaken to survey the changes in force and fatigue of the latissimus dorsi muscle during transformation into a fatigue-resistant muscle by indirect or nervous multichannel stimulation. In sheep, a silicone chamber connected to a pressure-transducing system was implanted under the left latissimus dorsi muscle. Muscle conditioning was performed by multichannel (carousel) stimulation of the thoracodorsal nerve. The program was started with active periods of 10 min/h producing 10 tetanic contractions/min. It was increased until 70 contractions/min could be performed during 24 h. The changes of muscle force and fatigue were monitored by the silicone balloon system. After a mean period of 22 weeks, fatigue resistance was reached. The fatigue-resistant muscle was able to produce a pressure of about 100 mm Hg in the balloon. After finishing the conditioning procedure, muscle forces and the fatigue resistance of the conditioned muscle were evaluated. The conditioned muscle showed only a minimal decrease of force during 20 min. Under a preload of 20 N, it exhibited a maximum tetanic tension of 95 N.
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