These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Chronic lymphocytic leukaemia: Clonal origin in a committed B-lymphocyte progenitor.
    Author: Fialkow PJ, Najfeld V, Reddy AL, Singer J, Steinmann L.
    Journal: Lancet; 1978 Aug 26; 2(8087):444-6. PubMed ID: 79806.
    Abstract:
    The glucose-6-phosphate dehydrogenase (G.-6-P.D.) types of isolated blood-cell populations and normal skin were determined in two patients with chronic lymphocytic leukaemia (C.L.L.) who were heterozygous at the G.-6-P.D. locus. Normal tissues from each patient manifested both A and B G.-6-P.D. types, but the C.L.L. B-lymphocyte preparation from one patient showed only a single enzyme type, and from the other patient it showed 95% activity of one G.-6-P.D. type. These observations confirm the supposition based on immunoglobulin-marker data that at the time of study C.L.L. has a clonal origin. In contrast to the B lymphocytes, granulocytes, erythrocytes, platelets, and T lymphocytes displayed both enzyme types in proportions similar to those found in skin. These findings indicate that C.L.L. involves committed B-lymphocyte progenitors. Thus, the disease stands in contrast to chronic myelocytic leukaemia and other myeloproliferative syndromes, all of which involve multipotent haemopoietic stem cells.
    [Abstract] [Full Text] [Related] [New Search]