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  • Title: CRF receptor antagonist attenuates stress-induced noradrenaline release in the medial prefrontal cortex of rats.
    Author: Shimizu N, Nakane H, Hori T, Hayashi Y.
    Journal: Brain Res; 1994 Aug 15; 654(1):145-8. PubMed ID: 7982086.
    Abstract:
    Noradrenaline release in rat medial prefrontal cortex (PFC) was measured using a brain microdialysis technique. Immobilization stress increased noradrenaline release to a maximum level of 248.7 +/- 12.8% of the basal release, which was significantly attenuated by preinjection of alpha-helical CRF9-41 (50 micrograms/rat) into the lateral cerebroventricle. Intracerebroventricular injection of CRF also increased noradrenaline release in the medial PFC. These results suggest that immobilization-stress facilitates noradrenaline release in the medial PFC through activation of the CRF system in the brain.
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