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  • Title: The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice.
    Author: Collins DR, Pertwee RG, Davies SN.
    Journal: Eur J Pharmacol; 1994 Jul 11; 259(3):R7-8. PubMed ID: 7982446.
    Abstract:
    Incubation of rat hippocampal slices with the synthetic cannabinoid (-)-11-OH-delta 8-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slices incubated with its non-psychoactive (+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimulation evoked a long-lasting potentiation, comparable to control slices.
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