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  • Title: Kinetics of splanchnic progesterone metabolism in ewes fed two levels of nutrition.
    Author: Freetly HC, Ferrell CL.
    Journal: J Anim Sci; 1994 Aug; 72(8):2107-12. PubMed ID: 7982841.
    Abstract:
    The objective of this study was to determine whether chronic nutritional treatment influences progesterone (P4) metabolism by splanchnic tissues and to develop a mathematical model of P4 metabolism in ewes. Five ovariectomized (ovx), multiparous ewes were assigned to a high feed intake and five multiparous ovx ewes were assigned to a low feed intake. The ewes with high feed intake received daily ME intakes of 99 kcal/BWkg.75, and the ewes with low intake received daily ME intakes of 63 kcal/BWkg.75. Catheters were placed surgically in the abdominal aorta, the portal vein, a branch of the hepatic vein, and a mesenteric vein. Blood and plasma flows across visceral organs were determined by marker dilution (p-aminohippuric acid), and P4 was determined with a RIA. The net splanchnic P4 flux and oxygen (O2) consumption were determined during five rates of P4 infusion into the jugular vein (112, 224, 449, 897, and 1,795 micrograms/h). Splanchnic O2 consumption was greater (P = .05) in the ewes with high feed intake. Net splanchnic P4 flux did not differ (P > .10) between nutritional treatments. The correlation between net splanchnic P4 flux and O2 consumption did not differ from zero (P = .69). Net splanchnic P4 flux was related linearly to plasma arterial P4 concentration. Splanchnic tissue clearance rate was 18% of the infusion rate. The behavior of the P4 model indicates that whole-body P4 metabolism is the sum of first-order kinetic reactions. The data indicate that splanchnic clearance of P4 is not affected by nutritional status.
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