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  • Title: [T-lymphocyte subpopulations in tuberculosis in middle aged and aged patients].
    Author: Adambekov DA.
    Journal: Probl Tuberk; 1993; (2):51-3. PubMed ID: 7984574.
    Abstract:
    The role of T-lymphocyte subpopulations in regulation of immunity was studied using monoclonal antibodies OKT-4 and OKT-8 in tuberculous patients and healthy subjects of different age. Basing on the examination of 174 patients, it was established that in older subjects pulmonary tuberculosis runs in the presence of aged-related changes in the immune system: an increase in the number of T-suppressors, a reduction in that of T-helpers, secondary immunodeficiency dependent on the process severity and forms. These shifts are suggested to be responsible for the inadequate immune response to M. tuberculosis in the elderly.
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