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  • Title: Determination of methaqualone and its metabolites in urine and blood by UV, GC/FID and GC/MS.
    Author: Liu F, Liu YT, Feng CL, Luo Y.
    Journal: Yao Xue Xue Bao; 1994; 29(8):610-6. PubMed ID: 7985519.
    Abstract:
    A systematic procedure for the determination of methaqualone and its metabolites in blood and urine by UV spectrophotometry, GC and GC/MS was developed. Urine and blood samples were from a suicidal patient who ingested 18 tablets of methaqualone. Both solid phase and liquid-liquid extractions were used in the extraction and clean-up of the samples. The total amount of methaqualone and its metabolites was measured by UV spectrophotometry. The amount of parent methaqualone was quantitated by GC/FID. Methaqualone and its 10 metabolites including two acetyl metabolites were found in urine and blood. This procedure is useful for monitoring drugs in emergency treatment.
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