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  • Title: Muscarinic receptor-mediated calcium efflux from cultured bovine adrenal chromaffin cells.
    Author: Houchi H, Masuda Y, Murakumo Y, Ishimura Y, Ohuchi T, Oka M.
    Journal: Biochem Pharmacol; 1994 Nov 16; 48(10):1982-5. PubMed ID: 7986212.
    Abstract:
    The effect of stimulation of the muscarinic receptor on Ca2+ mobilization in cultured bovine adrenal chromaffin cells was examined. Acetylcholine (ACh) increased the uptake of 45Ca2+ and [Ca2+]i whose levels decreased with time after reaching peaks. It also enhanced the efflux of 45Ca2+ from the cells. Its effect was inhibited by the specific muscarinic receptor antagonist atropine (Atr), but not by the nicotinic receptor antagonist hexamethonium (C6). The increase in muscarine (Mus)-stimulated 45Ca2+ efflux was reduced concentration-dependently by deprivation of extracellular Na+. These results suggest that muscarinic stimulation of the ACh receptor stimulates Na+/Ca2+ exchange in cultured bovine adrenal chromaffin cells.
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