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  • Title: Synthesis and antimicrobial activity of dihydrofurobenzoxazolin-2(3H)-ones and their derivatives.
    Author: Bhalerao UT, Gawali BB, Annapurna J.
    Journal: Arzneimittelforschung; 1994 Sep; 44(9):1077-9. PubMed ID: 7986248.
    Abstract:
    A series of dihydrofurobenzoxazolin-2(3H)-ones and their derivatives were synthesized. The structures of the compounds have been elucidated by IR, mass, 1H-NMR spectra and elementary analysis. The in vitro activity of these compounds was investigated against Gram-positive and Gram-negative bacteria and also against Candida albicans. 7,7-Dimethyl-7,8-dihydro-furo[2,3-g]benzoxazolin-2(3H)-one (compound 2) proved to be more potent than compound 1. Compound 3 also showed significant activity against all the microbes tested. Compounds 4 and 5 were more effective against Gram-positive bacteria than Gram-negative bacteria but inactive against C. albicans.
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