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  • Title: Review of investigative diagnostic techniques for cutaneous lymphoma.
    Author: Slater DN.
    Journal: Semin Dermatol; 1994 Sep; 13(3):166-71. PubMed ID: 7986684.
    Abstract:
    This article reviews the contribution of modern investigative techniques to the diagnosis of cutaneous lymphoproliferative diseases. Special attention is given to the significance of immunoglobulin and T-cell receptor rearrangements; as detected by Southern blotting and/or the polymerase chain reaction. Additional topics discussed include immunohistochemistry, cytogenetics, onco- and tumour suppressor genes and in-situ hybridization. It is recommended that the results of these techniques are interpreted in the form of a multifaceted diagnostic profile.
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