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  • Title: [Iomeprol: results of clinical trials with a new nonionic contrast medium in children].
    Author: van Gessel R, Möller A, Schmiedel E.
    Journal: Aktuelle Radiol; 1994 Sep; 4(5):225-8. PubMed ID: 7986838.
    Abstract:
    PURPOSE: To assess the tolerability of the newly developed nonionic contrast medium Iomeprol in pediatric patients. MATERIAL AND METHODS: A total of 438 patients (1 day-17 years) were enrolled in open-label phase III studies with Iomeprol in the most important radiologic, urologic, and cardiologic indications. Iomeprol was tested in five concentrations ranging from isotonic solutions of 150 mg iodine/ml up to 400 mg iodine/ml. Half of the patients were younger than 3 years. RESULTS: Apart from the mostly slight sensations of heat, pain, and taste, the following adverse events were observed independently of a causal relationship to the test compound: vomiting (1.8%), rise in blood pressure (1.8%), and restlessness (1.1%). The respective incidence of all other adverse events was below 1%. CONCLUSION: Iomeprol is a suitable and well-tolerated nonionic contrast medium for use in pediatric examinations.
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