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  • Title: Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice.
    Author: Held WA, O'Brien JG, Kerns K, Gallagher JF, Sigmund CD, Gross KW.
    Journal: Cancer Res; 1994 Dec 15; 54(24):6496-9. PubMed ID: 7987848.
    Abstract:
    s.c. and abdominal tumors from interspecific hybrid, transgenic mice containing the SV40 early region linked to a renin enhancer/promoter were analyzed for loss of heterozygosity to identify chromosomal regions involved in tumorigenesis. A very high frequency of loss of heterozygosity/partial loss of heterozygosity or allelic imbalance involving the distal regions of chromosome 8 was observed in the s.c. tumors (76%) with frequent amplification (3-6 times) of the corresponding proximal regions including Junb, suggesting that chromosome 8 breakage and amplification promotes tumorigenesis in these mice.
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