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  • Title: Antitussive effect of dihydroetorphine in mice.
    Author: Kamei J, Iwamoto Y, Suzuki T, Misawa M, Nagase H, Kasuya Y.
    Journal: Eur J Pharmacol; 1994 Aug 01; 260(2-3):257-9. PubMed ID: 7988653.
    Abstract:
    The present study examined the opioid receptors involved in the antitussive effect of dihydroetorphine in mice. Dihydroetorphine suppressed coughs dose dependently at doses between 0.1-1 micrograms/kg i.p. Blockade of mu-opioid receptors by pretreatment with beta-funaltrexamine significantly reduced the antitussive effect of dihydroetorphine. Furthermore, the antitussive effect of dihydroetorphine was also antagonized by nor-binaltorphimine, a kappa-opioid receptor antagonist. However, pretreatment with naltrindole, a delta-opioid receptor antagonist, did not affect the antitussive effect of dihydroetorphine. These results indicate that the antitussive effect of dihydroetorphine is mediated by the activation of mu-opioid receptors and of kappa-opioid receptors, but not delta-opioid receptors.
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