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  • Title: Primary extramedullary plasmacytoma in the middle ear: differential diagnosis and management.
    Author: Kandiloros DC, Nikolopoulos TP, Ferekidis EA, Kaloterakis AN, Papadimitriou CP, Adamopoulos GK.
    Journal: J Laryngol Otol; 1994 Oct; 108(10):868-70. PubMed ID: 7989836.
    Abstract:
    Primary extramedullary plasmacytoma (PEP) is an uncommon neoplasm of plasma cell origin which afflicts the head and neck mainly. In this study we report a rare case of a 34-year-old man who presented with left ear tinnitus, hearing loss, blocked feeling and headache. Exploratory tympanotomy revealed a mass extending into the attic and the mastoid antrum. Following canal wall-up mastoidectomy, the tumour was carefully removed. Histological examination (including immunoperoxidase staining) and thorough clinical, laboratory and radiological evaluation revealed an exclusively cytoplasmic monoclonal IgG immunoglobulin PEP. The combination of surgery (including a second-look procedure) and radiotherapy used in this case may be an over-treatment. However, the patient is still disease-free seven years after his first admission to hospital.
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