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  • Title: [Protein phosphatases: structure and function].
    Author: Bulanova EG, Budagian VM.
    Journal: Mol Biol (Mosk); 1994; 28(5):991-1001. PubMed ID: 7990844.
    Abstract:
    The process of protein and enzyme systems phosphorylation is necessary for cell growth, differentiation and preparation for division and mitosis. The conformation changes of protein as a result of phosphorylation lead to increased enzyme activity and enhanced affinity to substrates. A large group of enzymes--protein kinases--is responsible for phosphorylation process in cell, which are divided into tyrosine- and serine-threonine-kinases depending on their ability to phosphorylate appropriate amino acid residues. In this review has been considered the functional importance and structure of protein phosphatases--enzymes, which are functional antagonists of protein kinases.
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